Protein-induced tissue morphogenesis
US6565843B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 14, 1995 |
| Grant date | May 20, 2003 |
| Priority date | — |
| Expiry date | Mar 14, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods, compositions and devices for inducing tissue-specific regeneration in a mammal, or for stimulating proliferation of mammalian progenitor cells. The present methods, compositions and devices make use of osteogenic protein 1 (OP-1), which is appreciated herein as a tissue morphogen, i.e., a substance competent to induce tissue-specific morphogenesis of mammalian body tissues in addition to bone and/or cartilage. Alternatively, the present methods, compositions and devices make use of other naturally-occurring or biosynthetic proteins sharing a defined structural and functional relationship with OP-1 and thus appreciated herein also to function as tissue morphogens. Optionally, OP-1 or a related protein can be used alone or when adsorbed on a support matrix which provides an anchoring substratum for proliferation and/or differentiation of progenitor cells during tissue-specific morphogenesis. In another embodiment, OP-1 or a related protein is used to stimulate mammalian progenitor cells ex vivo, such that the stimulated cells, when disposed in vivo in a mammal, undergo tissue-specific morphogenesis to produce replacement tissue at a nonskeletal tissue …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.