Cadherin-like asymmetry protein-1, and methods for its use
US6565848B1 · kind B1 · utility
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14Claims
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Key dates
| Filing date | Apr 11, 2000 |
| Grant date | May 20, 2003 |
| Priority date | — |
| Expiry date | Apr 11, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to molecules involved in cell-cell interactions in the immune system. In particular, the invention relates to a cell surface protein which contains certain classical cadherin characteristics, but it exhibits an apical distribution pattern on the surface of lymphocytes. The membrane location of this molecule correlates with the contact interface between T and B cells, and antibodies against an extracellular domain of this protein disrupt T cell/B cell interactions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.