Compounds alkylating specific base sequence of DNA and method for synthesizing the same
US6566336B1 · kind B1 · utility
27Cited by
0References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 30, 2000 |
| Grant date | May 20, 2003 |
| Priority date | — |
| Expiry date | May 30, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides a compound recognizing the minor group of hydrogen bonds between base pairs and being capable of forming a covalent bond with bases. The inventive compound can recognize a specific nucleotide sequence and can strongly bind to adjacent bases via covalent bonding, to regulate the expression of a DNA with the nucleotide sequence. The invention provides a DNA alkylating agent comprising a compound represented by the general formula I: wherein R represents a lower amyl group or a polyamide group; and X represents nitrogen or CH.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.