Gene therapy by secretory gland expression

US6566342B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael German · San Francisco, US
• Ira D. Goldfine · Poway, US
• Stephen S. Rothman · Berkeley, US

Key dates

• Filing date: Jan 4, 2001
• Grant date: May 20, 2003
• Expiry date: Jan 18, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P5/48
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on a mammalian subject. The expressed protein is secreted directly into the gastrointestinal tract and/or blood stream to obtain therapeutic blood levels of the protein thereby treating the patient in need of the protein. The transformed secretory gland cells provide long term therapeutic cures for diseases associated with a deficiency in a particular protein or which are amenable to treatment by overexpression of a protein.