2-arachidonylglycerol (2-AG)-an inhibitor of tumor necrosis factor-&agr; and neuroprotector of brain in closed head injury

US6566543B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Raphael Mechoulam · Jerusalem, IL
• Ruth Gallily · Jerusalem, IL
• Aviva Breuer · Jerusalem, IL
• Esther Shohami · Mevaseret Tsiyon, IL
• David Panikashvili · Jerusalem, IL

Key dates

• Filing date: Jun 22, 2001
• Grant date: May 20, 2003
• Expiry date: Jul 5, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to 2-arachidonylglycerol (2-AG) to be used as inhibitor of a tumor necrosis factor (TNF-&agr;), in the reduction of edema caused by closed head injury, in the reduction of neurological deficits caused by closed head injury and stroke and in treating pathological conditions caused by TNF-&agr; and/or by radical oxygen intermediates (ROI), in pharmaceutical composition for the same use comprising as active ingredient 2-AG. It comprises also the use of 2-AG and pharmaceutical compositions comprising same in the preparation of a medicament for the treatment of said indications and methods of treatment by 2-AG and pharmaceutical compositions comprising same for diseases caused by said indications.