Prostate-specific membrane antigen and uses thereof
US6569432B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 29, 1996 |
| Grant date | May 27, 2003 |
| Priority date | — |
| Expiry date | Aug 29, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/342
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides an isolated nucleic acid molecule encoding an alternatively spliced human prostate-specific membrane antigen. This invention provides an isolated nucleic acid comprising a promoter sequence normally associated with the transcription of a gene encoding a human prostate-specific membrane antigen. This invention provides an isolated polypeptide having the biological activity of an alternatively spliced prostate-specific membrane antigen. This invention provides a method of detecting a nucleic acid encoding an alternatively spliced human prostate-specific membrane antigen and a method of detecting a prostate tumor cell in a subject. Lastly, this invention provides a pharmaceutical composition comprising a compound in a therapeutically effective amount and a pharmaceutically acceptable carrier and a method of making prostate cells susceptible to a cytotoxic chemotherapeutic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.