Combination of acid protease enzymes and acidic buffers and uses thereof
US6569437B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 16, 1999 |
| Grant date | May 27, 2003 |
| Priority date | — |
| Expiry date | Jul 16, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically 5 acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and/or for improving the texture or appearance of the skin, and/or for enhancing epidermal exfoliation and/or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes that exhibit proteolytic activity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. The acidic buffer comprises inorganic and/or organic acids or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient. The buffer is capable of reducing the pH of the surface of the skin to less than pH 5.5 and is susceptible to neutralization by normal epidermal processes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.