Process for producing small particles of biologically active molecules
US6569458B1 · kind B1 · utility
74Cited by
6References
10Claims
0Family size
Assignee
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Key dates
| Filing date | Jan 21, 1993 |
| Grant date | May 27, 2003 |
| Priority date | — |
| Expiry date | Jan 21, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1688
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0.1 to 10 micrometers with greater than 70 to 95% of the initial biological activity of the molecules in solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.