Modified adenoviral fiber and target adenoviruses
US6569677B1 · kind B1 · utility
24Cited by
1References
10Claims
0Family size
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Inventors
Key dates
| Filing date | Oct 4, 1999 |
| Grant date | May 27, 2003 |
| Priority date | — |
| Expiry date | Oct 4, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and a infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.