Pharmaceutical preparations containing estra-1,3,5(10)-triene derivatives

US6569844B1 · kind B1 · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Sigfrid Schwarz · Jena, DE
• Walter Elger · Berlin, DE
• Hans-Joachim Siemann · Jena, DE
• Gudrun Reddersen · Jena, DE
• Birgitt Schneider · Jena, DE

Key dates

• Filing date: Feb 2, 1998
• Grant date: May 27, 2003
• Expiry date: Feb 2, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J43/003
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns pharmaceutical preparations containing estra-1,3,5(10)-triene derivatives as active ingredients which carry a group of the general formulaR—SO2—O—at their C3 position whereinR is a R1R2N group whereinR1 and R2 are independent of each other and represent a hydrogen atom, a C1-C5 alkyl radical or, together with the N atom, a polymethylene imino radical containing 4 to 6 C atoms, or a morpholino radical.The preparations according to the invention can be used for hormonal contraception and for hormon replacement therapy (HRT). They exhibit a low hepatic estrogenity.