Substituted 4-amino-thiazol-2-yl compounds as cyclin-dependent kinase inhibitors
US6569878B1 · kind B1 · utility
9Cited by
30References
20Claims
0Family size
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Key dates
| Filing date | Oct 27, 1998 |
| Grant date | May 27, 2003 |
| Priority date | — |
| Expiry date | Oct 27, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions containing effective amounts of CDK-inhibiting diaminothiazole compounds of the following formula (where R1 and R2 are as defined in the specification) or their salts, or prodrugs or active metabolites of such compounds or salts, are useful for treating disorders and diseases such as cancer: In preferred embodiments, R1 and R2 are independently unsubstituted or substituted carbocyclic or heterocyclic aryl ring structures. Compounds where R2 is ortho-substituted aryl are especially potent inhibitors of CDKs such as CDK4.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.