Preparation of dialkylpyridylboranes
US6570017B2 · kind B2 · utility
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15Claims
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Assignee
Inventor
Key dates
| Filing date | Aug 23, 2002 |
| Grant date | May 27, 2003 |
| Priority date | — |
| Expiry date | Aug 23, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to method for the preparation of dialkylpyridylboranes by reacting a pyridine Grignard reagent with an alkoxydialkylborane or a trialkylborane. The reaction can be conducted at a temperature ranging from about 0° C. to about 40° C. The pyridine Grignard reagent is preferably prepared in situ by the reaction of a Grignard reagent (RMgX) and a halopyridine in a suitable solvent, such as tetrahydrofuran, followed by the addition of an alkoxydialkylborane or a trialkylborane to form a dialkylpyridylborane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.