Combined fluorescence and reflectance spectroscopy

US6571118B1 · kind B1 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Urs Utzinger · Tucson, US
• Anthony J. Durkin · Irvine, US
• Holger Fuchs · Aalen, DE
• Ann M. Gillenwater · Pearland, US
• Douglas L. Heintzelman · Plainfield, US
• Rebecca Richards-Kortum · Austin, US

Key dates

• Filing date: May 4, 1999
• Grant date: May 27, 2003
• Expiry date: May 4, 2019

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2021/6484
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods and apparatus for performing fluorescence and spatially resolved reflectance spectroscopy on a sample. A sample is irradiated with a fluorescence excitation fiber and radiation is collected from the sample with a fluorescence collection fiber and detected to form fluorescence spectra. The sample is also illuminated with a reflectance illumination fiber and reflected light from the sample is collected at a plurality of collection positions and detected to form spatially resolved reflectance spectra. The fibers may form a probe arranged in concentric sections. The spectra are analyzed by pre-processing and reducing the dimensionality of the spectral data.