Recombinant human beta interferon with enhanced solubility

US6572853B1 · kind B1 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Christian Schneider-Fresenius · Hannover, DE
• Bernd Otto · Hannover, DE
• Gero Waschutza · Meinersen, DE

Key dates

• Filing date: Feb 22, 2000
• Grant date: Jun 3, 2003
• Expiry date: Feb 22, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/565
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu(5), Phe(8), Phe(15), Leu(47), Phe(50), Leu(106), Phe(111), Leu(116), Leu(120) and Phe(156) is exchanged with hydrophilic amino acid with a hydroxy group, specially serine, tyrosine or threonine, resulting in enhanced hydrophilic property of the protein surface.