Non-anaphylactic forms of grass pollen Phl p 6 allergen and their use

US6572859B1 · kind B1 · utility

Assignees

• Pharmacia Diagnostics AB · SE
• Rudolf Valenta · AT

Inventors

• Rudolf Valenta · Theresienfeld, AT
• Susanne Vrtala · Wien, AT
• Sabine Stummfoll · St. Peter, AT
• Hans Grönlund · Lidingö, SE
• Monika Grote · Hachenburg, DE
• Luca Vangelista · Padova, IT
• Annalisa Pastore · London, GB
• Wolfgang Sperr · Wien, AT
• Peter Valent · Wien, AT
• Dietrich Kraft · Wien, AT

Key dates

• Filing date: Oct 26, 2000
• Grant date: Jun 3, 2003
• Expiry date: Oct 26, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/868
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p6 molecule has an N-terminal and/or C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity. The invention also relates to a hypoallergenic immunogenic combination of molecules derived from the Phl p 6 allergen, comprising (i) a Phl p 6 molecule having an N-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, and (ii) a Phl p 6 molecule having a C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, which two molecules together encompass the complete sequence of Phl p 6. The invention further relates to the use of the hypoallergenic immunogenic molecule or molecule mixture in hyposensitization and diagnosis.