Process for the deacylation of cyclic lipopeptides
US6573084B1 · kind B1 · utility
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21Claims
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Key dates
| Filing date | Sep 6, 2000 |
| Grant date | Jun 3, 2003 |
| Priority date | — |
| Expiry date | Sep 6, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/465
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase. [wherein R1 is acyl;R2 is hydroxy or acyloxy;R3 is hydrogen or hydroxy;R4 is hydrogen or hydroxy;R5 is hydrogen or hydroxysulfonyloxy; andR6 is hydrogen or carbamoyl.]
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.