Anti-viral pyrimidine nucleoside analogues

US6573247B1 · kind B1 · utility

Assignees

• University College Cardiff Consultants Limited · GB
• Rega Foundation · BE

Inventors

• Christopher McGuigan · Cardiff, GB
• Christopher John Yarnold · Shrewsbury, GB
• Garry Jones · West Liberty, US
• Jan Balzarini · Heverlee, BE
• Erik De Clercq · Lovenjoel, BE

Key dates

• Filing date: Jan 6, 2000
• Grant date: Jun 3, 2003
• Expiry date: Jan 6, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound having formula (I), wherein R is selected from the group comprising C5 to C20 alkyl, C5 to C20 cycloalkyl, halogens, aryl and alkylaryl; R′ is selected from the group comprising hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, alkyl; R″ is selected from the group comprising hydrogen, alkyl, cycloalkyl, halogens, alkyloxy, aryloxy and aryl; Q is selected from the group comprising O, S and CY2, where Y may be the same or different and is selected from H, alkyl and halogens; X is selected from the group comprising O, NH, S, N-alkyl, (CH2)n where n is 1 to 10, and CY2 where Y may be the same or different and is selected from hydrogen, alkyl and halogens; Z is selected from the group comprising O, S, NH, and N alkyl; U″ is H and U′ is selected from H and CH2T, or U′ and U″ are joined so as to form a ring moiety including Q wherein U′-U″ together is respectively selected from the group comprising —CTH—CT′T″— and —CT═CT— and —CT′═CT′—, so as to provide ring moieties selecte…