Antibacterial compounds

US6573272B1 · kind B1 · utility

Assignee

• Affinium Pharmaceuticals, Inc. · CA

Inventors

• William Henry Miller · Collegeville, US
• Kenneth A. Newlander · West Chester, US
• Mark A. Seefeld · Collegeville, US

Key dates

• Filing date: Nov 28, 2001
• Grant date: Jun 3, 2003
• Expiry date: Nov 28, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I) are disclosed which are FabI inhibitors and are useful in the treatment bacterial infections: wherein:R1 is Ar or Het;R2 is H, C1-6alkyl or Ar—C0-6alkyl;X is H, C1-4alkyl, OR′, SR′, C1-4alkylsulfonyl, C1-4alkylsulfoxyl, CN, N(R′)2, CH2N(R′)2, NO2, CF3, CO2R′, CON(R′)2, COR′, NR′C(O)R′, F, Cl, Br, I, or CF3S(O)r—;R′ is H, C1-6alkyl or Ar—C0-6alkyl; andr is 0, 1 or 2;or a pharmaceutically acceptable salt thereof.