Substituted sulphonyl cyanamides, method for producing same and their use as medicament

US6573288B1 · kind B1 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Andreas Weichert · Egelsbach, DE
• Hans-Jochen Lang · Hofheim, DE
• Stefan Petry · Kelkheim, DE
• Jan-Robert Schwark · Frankfurt am Main, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Sabine Faber · Idstein, DE
• Hans-Willi Jansen · Niedernhausen, DE

Key dates

• Filing date: Nov 3, 2000
• Grant date: Jun 3, 2003
• Expiry date: Nov 3, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/68
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of formula (I) in which the symbols have the meanings given in the claims. Said compounds are inhibitors of the sodium-dependent bicarbonate/chloride ion exchanger which can be used as medicines for the prophylaxis or treatment of a wide range of diseases, for example the treatment and/or prophylaxis of myocardial infarction, angina pectoris, diseases caused by ischaemia, impaired respiration, cardiac ischaemia, ischaemia of the peripheral and central nervous system and stroke, ischaemia of the peripheral organs and limbs and diseases in which cell proliferation is a primary or secondary cause, in the treatment of shock, during surgical interventions and organ transplants or for preserving and storing transplants to be used in surgical interventions.