Iron-containing nanoparticles with double coating and their use in diagnosis and therapy

US6576221B1 · kind B1 · utility

Assignees

• Institut fur Diagnosikforschung GmbH · DE
• Der Freien Universitat Berline · DE

Inventors

• Mayk Kresse · Berlin, DE
• Detlev Pfefferer · Berlin, DE
• Rüdiger Lawaczek · Berlin, DE
• Susanne Wagner · Mittenwalde, DE
• Wolfgang Ebert · Krefeld, DE
• Volker Elste · Berlin, DE
• Wolfhard Semmler · Glienicke, DE
• Matthias Taupitz · Teltow, DE
• Josef Gaida · Berlin, DE
• Anja Herrmann · Berlin, DE
• Monika Jukl · Berlin, DE
• Udo Swiderski · Berlin, DE

Key dates

• Filing date: Nov 30, 1999
• Grant date: Jun 10, 2003
• Expiry date: Nov 30, 2019

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2446/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes.The nanoparticles according to the invention are characterized in that they consist of an iron-containing core, a primary coat (synthesis polymer), and a secondary coat (targeting polymer) and, optionally, of pharmaceutic adjuvants, pharmaceuticals, and/or adsorption mediators/enhancers.