Angiogenic homing molecules and conjugates derived therefrom
US6576239B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1997 |
| Grant date | Jun 10, 2003 |
| Priority date | — |
| Expiry date | Sep 10, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/948
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a selected tumor or to identify the target molecule expressed by the tumor. The invention also provides methods of targeting a tumor containing angiogenic vasculature by contacting the tumor with a molecule that specifically binds an &agr;v-containing integrin. The invention further provides molecules that can selectively home to angiogenic vasculature. In addition, the invention provides a target molecule, which is specifically bound by a tumor homing molecule and is expressed by angiogenic vasculature. The invention also provides antibodies that bind to the target molecule and peptidomimetics that competitively inhibit binding of a ligand to the target molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.