Sample preparation and detection device for infectious agents

US6576459B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Robin R. Miles · Danville, US
• Amy Wang · Hayward, US
• Christopher K. Fuller · Livermore, US
• Asuncion V. Lemoff · Union City, US
• Kerry Bettencourt · Dublin, US
• June Yu · Livermore, US

Key dates

• Filing date: Mar 23, 2001
• Grant date: Jun 10, 2003
• Expiry date: Oct 24, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/962
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A sample preparation and analysis device which incorporates both immunoassays and PCR assays in one compact, field-portable microchip. The device provides new capabilities in fluid and particle control which allows the building of a fluidic chip with no moving parts, thus decreasing fabrication cost and increasing the robustness of the device. The device can operate in a true continuous (not batch) mode. The device incorporates magnetohydrodynamic (MHD) pumps to move the fluid through the system, acoustic mixing and fractionation, dielectropheretic (DEP) sample concentration and purification, and on-chip optical detection capabilities.