Use of dopamine receptor antagonists in palliative tumor therapy

US6576624B1 · kind B1 · utility

Assignee

• Zentaris GmbH · DE

Inventors

• Bernd Nickel · Mühltal, DE
• Peter Hilgard · Frankfurt, DE
• Thomas Klenner · Ingelheim am Rhein, DE
• Jurgen Engel · Alzenau, DE

Key dates

• Filing date: Jun 23, 2000
• Grant date: Jun 10, 2003
• Expiry date: Jun 23, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.