Patent · US Expired

Z-styryl sulfone anticancer agents

US6576675B1 · kind B1 · utility

10Cited by

10References

14Claims

0Family size

Assignee

Temple University-Of The Commonwealth System of Higher Education · US

Inventors

E. Premkumar Reddy · Villanova, US
M. V. Ramana Reddy · Upper Darby, US

Key dates

Filing date	Sep 28, 2001
Grant date	Jun 10, 2003
Priority date	—
Expiry date	Sep 28, 2021

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C323/07
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

(Z)-styryl benzylsulfones of formula I are useful as anticancer agents: whereinR1 is selected from the group consisting of hydrogen, chloro and nitro;R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, iodo and fluoro; andR3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, iodo and fluoro;provided that at least one of R1 or R2 is hydrogen.The corresponding (Z)-styryl benzylsulfides are useful as intermediates in the preparation of the biologically active (Z)-styryl benzyl sulfones.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.