Methods for the assay of troponin I and T complexes of troponin I and T and selection of antibodies for use in immunoassays
US6579687B1 · kind B1 · utility
17Cited by
6References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 21, 1999 |
| Grant date | Jun 17, 2003 |
| Priority date | — |
| Expiry date | Oct 21, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/819
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and compositions are described for the detection and quantitation of cardiac specific troponin I and troponin T in samples. Cardiac-specific troponin isoforms exist in various forms in the blood, including free and complexed forms. By selecting antibodies that are sensitive and/or insensitive to these various forms, the present invention can provide immunoassays that more accurately reflect the clinical state of an individual. These described methods and compositions can be used for providing indicators of myocardial infarction and other cardiac pathologies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.