Mammalian tolloid-like gene and protein
US6579702B2 · kind B2 · utility
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Key dates
| Filing date | Apr 2, 1999 |
| Grant date | Jun 17, 2003 |
| Priority date | — |
| Expiry date | Apr 2, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld and distinct from human or murine mTll-1 is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein having distinct activities. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.
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