1&agr;-hydroxy-2-methylene-19-nor-homopregnacalciferol and its uses
US6579861B2 · kind B2 · utility
66Cited by
12References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 7, 2002 |
| Grant date | Jun 17, 2003 |
| Priority date | — |
| Expiry date | Jun 7, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C401/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention discloses 1&agr;-hydroxy-2-methylene-19-nor-homopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat immune disorders in humans as well as renal osteodystrophy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.