Method of treating hyperlipidemic and hyperglycemic conditions in mammals using pregnadienols and pregnadienones

US6579862B1 · kind B1 · utility

Assignee

• COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH · IN

Inventors

• Ram Pratap · Lucknow, IN
• Ram Gupta · Lucknow, IN
• Ramesh Chander · Lucknow, IN
• Ashok Kumar Khanna · Lucknow, IN
• Arvind Kumar Srivastava · Lucknow, IN
• Deepak Raina · Lucknow, IN
• Satyavan Singh · Lucknow, IN
• Savita Srivastava · Lucknow, IN
• Anil Kumar Rastogi · Lucknow, IN
• Omkar Prasad Asthana · Lucknow, IN
• Swarn Nityanand · Lucknow, IN
• Nitya Anand · Lucknow, IN
• Ashim Ghatak · Lucknow, IN
• Narinder Kumar Kapoor · Lucknow, IN
• Sukh Dev · Lucknow, IN

Key dates

• Filing date: Mar 30, 1999
• Grant date: Jun 17, 2003
• Expiry date: Mar 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J13/007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I): containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals wherein X═OH or O and the olefinic bonds are at 4(5); 5(6); 16(17); or 17(20) or various combinations, and wherein the compounds contain at lest one olefinic bond in or on their D-ring. The method comprises administering an effective amount of said compounds to recipient mammals.