Prolines as antimicrobial agents

US6579894B2 · kind B2 · utility

Assignees

• MERCK & CO., INC. · US
• Cubist Pharmaceuticals LLC · US

Inventors

• Milton L. Hammond · Somerville, US
• Aaron H. Leeman · Cranford, US
• Milana Maletic · Summit, US
• Gina M. Santorelli · Long Branch, US
• Sherman T. Waddell · Westfield, US
• John Finn · Mercerville, US
• Michael Morytko · Framingham, US
• Siya Ram · Winchester, US
• Dennis Keith · Montclair, US

Key dates

• Filing date: Jun 17, 2002
• Grant date: Jun 17, 2003
• Expiry date: Jun 17, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; L is —C(O)N(Q)CH2—, or —CR10R11OCR12R13—; Q is hydrido, —(CH2)mCO2H and —(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.