Preparation of quinoline-substituted carbonate and carbamate derivatives

US6579986B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Michael S. Allen · Spooner, US
• Ramiya H. Premchandran · Gurnee, US
• Sou-Jen Chang · Prairie View, US
• Stephen Condon · Kenosha, US
• John DeMattei · San Diego, US
• Steven A. King · Gurnee, US
• Lawrence Kolaczkowski · Gurnee, US
• Sukumar Manna · Libertyville, US
• Paul Nichols · Firestone, US
• Hemant H. Patel · Edison, US
• Subhash R. Patel · Chicago, US
• Daniel Plata · Wadsworth, US
• Eric J. Stoner · Kenosha, US
• Jien-Heh J. Tien · Libertyville, US
• Steven J. Wittenberger · Mundelein, US

Key dates

• Filing date: Apr 29, 2002
• Grant date: Jun 17, 2003
• Expiry date: Apr 29, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C68/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.