Composition and device for in vivo cartilage repair

US6582471B1 · kind B1 · utility

Assignee

• Sulzer Innotec AG · CH

Inventors

• Pedro Bittmann · Zürich, CH
• Brent Atkinson · Highlands Ranch, US
• James J. Benedict · Cincinnati, US
• John Ranieri · Austin, US
• Marsha Whitney · Austin, US
• Donald E. Chickering, III · Framingham, US

Key dates

• Filing date: Sep 13, 2000
• Grant date: Jun 24, 2003
• Expiry date: Sep 13, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/914
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)-lactic acid/glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device compri…