Method and a device for the evaluation of biopolymer fitness

US6582903B1 · kind B1 · utility

Assignee

• Evotec OAI AG · DE

Inventors

• Rudolf Rigler · Djursholm, SE
• Manfred Eigen · Göttingen, DE
• Karsten Henco · Erkrath, DE
• Ulo Mets · Tallinn, EE
• Jerker Widengren · Solna, SE
• Michael Stuke · Göttingen, DE
• Michael Brinkmeyer · Göttingen, DE
• Wolfgang Simm · Lausanne, CH
• Olaf Lehmann · Göttingen, DE

Key dates

• Filing date: Feb 10, 1998
• Grant date: Jun 24, 2003
• Expiry date: Feb 10, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/11
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for identifying one or a small number of molecules, especially in a dilution of ≦1 &mgr;M, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.