Propenyl cephalosporin derivatives and process for the manufacture thereof

US6583133B1 · kind B1 · utility

Assignee

• Basilea Pharmaceutica AG · CH

Inventors

• Peter Angehrn · Böckten, CH
• Erwin Gotschi · Reinach, CH
• Ingrid Heinze-Krauss · Schliengen, DE
• Hans Richter · Weil am Rhein, DE

Key dates

• Filing date: Jun 22, 1999
• Grant date: Jun 24, 2003
• Expiry date: Jun 22, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are cephalosporin derivatives of the general formula wherein R is an organic residue with a molecular weight not exceeding 400 bonded to the adjacent sulphur atom via carbon and consisting of carbon, hydrogen, and optional oxygen, sulfur, nitrogen and/or halogen atoms; R1 is hydrogen, lower alkyl or phenyl; and A is a secondary, tertiary or quaternary nitrogen atom bound directly to the propenyl group and being substituted by an organic residue with a molecular weight not exceeding 400 and consisting of carbon, hydrogen, and optional oxygen, sulfur, nitrogen and/or halogen atoms,as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts.