Process for obtaining compounds usable in the production of Cefotetan, and new compounds obtained thereby
US6583291B2 · kind B2 · utility
1Cited by
4References
11Claims
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Key dates
| Filing date | Apr 17, 2002 |
| Grant date | Jun 24, 2003 |
| Priority date | — |
| Expiry date | Apr 17, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A safe and economical process for obtaining salts of 4-carboxy-3-hydroxy-5-mercapto-isothiazole. This process comprises refluxing a disodium or dipotassium salt of 3-hydroxy-5-mercapto-4-isothiazole carbonitrile in an aqueous solution of sodium or potassium hydroxide to produce the desired salt. The desired salt may be precipitated out of solution by adjusting the pH downward to a minimum value of about pH 8. Compounds produced by this process may be used for producing semi-synthetic cephalosporins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.