Genotyping the human UDP-glucuronosyltransferase 2B7 (UGT2B7) gene
US6586175B1 · kind B1 · utility
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Key dates
| Filing date | Jul 20, 1999 |
| Grant date | Jul 1, 2003 |
| Priority date | — |
| Expiry date | Jul 20, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Genetic polymorphisms are identified in the human UGT2B4, UGT2B7 and UGT2B15 genes that alter UGT2B activity. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT2B substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
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