Patent · US Expired

Method for identification of compounds that bind to &bgr;-tubulin and stimulate insulin secretion

US6586188B1 · kind B1 · utility

1Cited by

0References

21Claims

0Family size

Assignee

Biovitrum AB · SE

Inventors

Per-Olof Berggren · Solna, SE
Thomas Lundback · Nacka, SE
Alejandro Bertorello · Stockholm, SE

Key dates

Filing date	Aug 11, 2000
Grant date	Jul 1, 2003
Priority date	—
Expiry date	Aug 11, 2020

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/566
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

According to the invention &bgr;-tubulin, as well as a 65 kDa polypeptide present in pancreatic &bgr;-cells, have been identified as molecular targets for sulfonylurea compounds. These findings enable for the identification of new insulin secretagogues. The invention thus relates to the use of sulfonylurea compounds, such as e.g. glibenclamide, in methods for identification of compounds binding the 65 kDa polypeptide or tubulin, or stimulating tubulin polymerization and/or turnover, thereby stimulating insulin secretion.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.