Method of identifying compounds that bind galanin receptor (GALR2)

US6586191B2 · kind B2 · utility

Assignee

• Synaptic Pharmaceutical Corporation · US

Inventors

• Kelli E. Smith · Wayne, US
• David L. Linemeyer · Guilford, US
• Christophe P. G. Gerald · Ridgewood, US
• Theresa Branchek · Teaneck, US
• Richard L. Weinshank · Teaneck, US
• Carlos Forray · Paramus, US

Key dates

• Filing date: Jul 23, 1997
• Grant date: Jul 1, 2003
• Expiry date: Jul 23, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K48/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.