Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
US6586214B1 · kind B1 · utility
22Cited by
1References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 15, 1999 |
| Grant date | Jul 1, 2003 |
| Priority date | — |
| Expiry date | Sep 15, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y503/01009
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to isolated polynucleotides coding for phosphoglucose isomerase (pgi) from coryneform bacteria. In addition, the invention includes methods for increasing the metabolic flux through pentose phosphate cycle of bacteria by reducing or eliminating the activity of pgi. These methods may be used to increase the fermentative production of nucleotides, vitamins and amino acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.