Method of using recombinant osteogenic protein to repair bone or cartilage defects
US6586388B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 24, 1997 |
| Grant date | Jul 1, 2003 |
| Priority date | — |
| Expiry date | Oct 24, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.