Subcutaneous administration of natriuretic peptide
US6586396B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 7, 1999 |
| Grant date | Jul 1, 2003 |
| Priority date | — |
| Expiry date | Apr 7, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/622
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically. The invention peptides have the formula:R1-Cys-Phe-Gly-Arg-Arg-/-Leu/-Asp-Arg-(1)                   Lys  Met    Ile-Gly/-Ser-Leu/-Ser-Gly-Leu-Gly-Cys-R2       Ser      Serwherein R1 is selected from the group consisting of:                                    &…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.