Non-covalent inhibitors of urokinase and blood vessel formation
US6586405B2 · kind B2 · utility
19Cited by
1References
90Claims
0Family size
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Key dates
| Filing date | Dec 7, 2000 |
| Grant date | Jul 1, 2003 |
| Priority date | — |
| Expiry date | Dec 7, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have P1 a group having an amidino or guanidino moiety or derivative thereof. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.