Amidino compounds useful as nitric oxide synthase inhibitors

US6586474B2 · kind B2 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Ronald Keith Webber · Holden, US
• Richard C. Durley · Chesterfield, US
• Alok K. Awasthi · Skokie, US
• Arija A. Bergmanis · Plainfield, US
• Kam F. Fok · Chesterfield, US
• Scott Ganser · Chicago, US
• Timothy J. Hagen · Gurnee, US
• E. Ann Hallinan · Evanston, US
• Donald W. Hansen, Jr. · Chicago, US
• Brian S. Hickory · Wildwood, US
• Pamela T. Manning · Chesterfield, US
• Michael K. Mao · Chesterfield, US
• Alan E. Moormann · Weldon Spring, US
• Barnett S. Pitzele · Skokie, US
• Michelle Promo · Chesterfield, US
• Richard Schartman · Evanston, US
• Jeffrey A. Scholten · Chesterfield, US
• Jeffrey S. Snyder · Manchester, US
• Mihaly V. Toth · Chesterfield, US
• Mahima Trivedi · Glenview, US
• Sofya Tsymbalov · Skokie, US
• Foe S. Tjoeng · Manchester, US

Key dates

• Filing date: Mar 23, 2001
• Grant date: Jul 1, 2003
• Expiry date: Mar 23, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.