Patent · US Expired

Efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines

US6586593B1 · kind B1 · utility

1Cited by

2References

26Claims

0Family size

Assignee

Brantford Chemicals Inc. · CA

Inventors

Bhaskar Reddy Guntoori · Brantford, CA
Daqing Che · Taizhou City, CN
K. S. Keshava Murthy · Brantford, CA

Key dates

Filing date	Jan 16, 2002
Grant date	Jul 1, 2003
Priority date	—
Expiry date	Jan 16, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D253/075
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for the manufacture of 3,5-diamino-6-substituted-1,2,4-triazines is disclosed which comprises the steps of:(a) reacting a compound of formula (II):  with aminoguanidine salts,(b) dehydrating the compound obtained to form a compound of formula IV,  and(c) cyclization of the compound of formula IV into a 3,5-diamino-6-substituted-1,2,4-triazine compound of formula I or into a hydrated form thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.