Method for induction of differentiation of osteoclasts
US6589528B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 6, 2001 |
| Grant date | Jul 8, 2003 |
| Priority date | — |
| Expiry date | Nov 6, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a simple method of producing osteoclasts from monocytes, a agent comprising monoclonal antibody to be used for the method, and a method for screening a ligand that induces differentiation of monocytes to osteoclasts. Differentiation of monocytes to osteoclasts can be induced in vitro by culturing isolated human peripheral blood monocytes in the presence of monoclonal antibody that binds to a portion of FRP-1 protein exposed on the surface of monocytes. Such a differentiation system can be utilized to isolate a ligand that binds to FRP-1 protein and induces differentiation of monocytes to osteoclasts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.