Controlled drug delivery system using the conjugation of drug to biodegradable polyester
US6589548B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 14, 2000 |
| Grant date | Jul 8, 2003 |
| Priority date | — |
| Expiry date | Nov 14, 2020 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect, Moreover, a high loading efficiency of hydrophilic drugs can be achieved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.