Pediatric formulation of gatifloxacin
US6589955B2 · kind B2 · utility
1Cited by
8References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 9, 2002 |
| Grant date | Jul 8, 2003 |
| Priority date | — |
| Expiry date | May 9, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is provided in accordance with the present invention the quinolone antibacterial gatifloxacin adequately taste-masked so that it can be utilized for pediatric formulations. A crystalline co-precipitate of gatifloxacin and one or both of stearic acid and palmitic acid in a narrow weight ratio has been found to effectively mask the bitter taste of gatifloxacin. The taste of gatifloxacin is effectively masked in the mouth and in aqueous suspension through a full dosage cycle, typically fourteen days. Gatifloxacin in the subject crystalline co-precipitates has been found to be readily available for absorption from the stomach.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.