Hydromorphone and hydrocodone compositions and methods for their synthesis
US6589960B2 · kind B2 · utility
40Cited by
0References
29Claims
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Assignee
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Key dates
| Filing date | Sep 27, 2002 |
| Grant date | Jul 8, 2003 |
| Priority date | — |
| Expiry date | Sep 27, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for the preparation of a ketone from a narcotic alkaloid having an allyl alcohol moiety is disclosed. The method includes mixing the narcotic alkaloid with an acid in the presence of a catalyst wherein the method is carried out in the substantial absence of hydrogen gas. The method is useful for preparing hydromorphone and hydrocodone compositions having novel impurity profiles. Compositions comprising hydromorphone and hydrocodone are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.