Preparation of selective cyclooxygenase II inhibitors

US6589973B1 · kind B1 · utility

Assignee

• THEMIS MEDICARE LIMITED · IN

Inventors

• Dinesh Patel · Narayanpur, IN
• Sachin Patel · Mumbai, IN
• Shashikant Prabhudas KURANI · Mumbai, IN

Key dates

• Filing date: May 15, 2002
• Grant date: Jul 8, 2003
• Expiry date: May 15, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A clear, stable novel pharmaceutical preparation of selective cyclooxygenase II inhibitors (COX 2) inhibitors in the parenteral form for the treatment of pain & inflammatory conditions arising because of cyclooxygenase-2 activity. In particular the pharmaceutical preparation of COX 2 inhibitors comprise of selective active COX 2 inhibitors selected from Celeoxib, Rofecoxib and their analogs dissolved in a selective isosorbide type solvent of following general formula I where R1 and R2 are hydrogen or alkyl chains containing 1-3 carbons or acetate group. Also disclosed is a simple and cost effective process of manufacture of the above novel pharmaceutical preparation.