Benzofurylpyrone derivatives

US6589984B1 · kind B1 · utility

Assignees

• TEIJIN LIMITED · JP
• MICROBIAL CHEMISTRY RESEARCH FOUNDATION · JP

Inventors

• Yoshimitsu Naniwa · Hino, JP
• Hiroshi Imai · Hino, JP
• Tomohide Ida · Hino, JP
• Emiko Muratani · Hino, JP
• Kazuo Kitai · Hino, JP
• Yoshinori Sugimoto · Hino, JP
• Tomomi Kosugi · Hino, JP
• Akiko Takeuchi · Tokyo, JP
• Kunihito Watanabe · Hino, JP
• Takami Tomiyama · Sakai, JP
• Tomio Takeuchi · Tokyo, JP
• Masa Hamada · Hoya, DE

Key dates

• Filing date: Sep 11, 2000
• Grant date: Jul 8, 2003
• Expiry date: Sep 11, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There is provided benzofuryl-&agr;-pyrone derivative represented by the following structural formula (I): whereinR1 represents a hydrogen atom or an alkyl group of 1 to 5 carbons;R2 represents hydrogen, —CO—R5 or —SO2R6;R3 represents hydrogen, an alkyl group of 1 to 5 carbons, etc.; andR4 is a substituent attached to the 4-carbon, 5-carbon, 6-carbon or 7 carbon of the benzofuran ring; and their salts. The compounds are useful as therapeutic agent for hypertriglyceridemia, lipid metabolism enhancers, or prophylactic and/or therapeutic agents for arteriosclerosis.