Methods of treating anxiety disorders

US6589986B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Mark Bowlby · Richboro, US
• Sharon Rosenzweig-Lipson · East Brunswick Township, US

Key dates

• Filing date: Dec 17, 2001
• Grant date: Jul 8, 2003
• Expiry date: Dec 17, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides methods for treating, preventing or inhibiting anxiety, anxiety-related conditions and phobias in a mammal using compounds of the formula: wherein: R1 is H, alkyl, alkanoyl or the radical Ar; R2 is H or alkyl; R3 is alkoxy, NH2, alkylamino, dialkylamino, amino substituted by the radical Ar, alkyl, alkenyl, alkynyl, or the radicals Ar or ArO—; R4 is H, alkyl or the radical Ar; R5 is H or alkyl or the radical Ar; or a pharmaceutically acceptable salt or ester form thereof; Ar is an optionally substituted phenyl radical; and n is 0 or 1, or a pharmaceutically acceptable salt or ester form thereof, with the methods particularly including the use of N-[2-amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester, also known as retigabine.